Dictionary > Prostaglandin F2-alpha

Prostaglandin F2-alpha

Definition
noun, plural: prostaglandins F
A biologically active prostaglandin that forms when the intermediate prostaglandin H2 reacts with aldose reductase, has a chemical formula of C20H34O5, and can react with and activate prostaglandin F receptors (FPs) leading to the contraction of certain smooth muscle tissues, such as the uterus
Supplement
Prostaglandin is an eicosanoid that is derived from unsaturated 20-carbon fatty acids, such as arachidonic acid, through the cyclooxygenase pathway. There are several prostaglandins and they are designated by appending a letter, i.e. from A to I, to indicate the type of substituents found on the hydrocarbon skeleton. There are four major types of prostaglandins produced biosynthetically: prostaglandin E2 (PGE2), prostacyclin (PGI2), prostaglandin D2 (PGD2) and prostaglandin F (PGF).
PGF series is a group of prostaglandins. An example is prostaglandin F2-alpha (PGF) naturally produced in the body, e.g. by uterus, airways, eyes, and vascular smooth muscle cells. Just like the other prostaglandins, PGFs are derived from arachidonic acid and then reacts with cyclooxygenase receptors (particularly, COX-1 and COX-2) to produce prostaglandin H2 (prostaglandin intermediate). When prostaglandin H2 reacts with aldose reductase (AKR1B1), PGF) is formed.
PGF has a chemical formula of C20H34O5. When PGF reacts with prostaglandin F receptors (FPs), it causes contraction of certain smooth muscle tissues, such as uterus. Thus, it is involved in bronchoconstriction and uterine contraction.
As a medication, PGF is used to induce labor. In higher dosage, PGF) acts as an abortifacient. It causes pregnancy termination since it acts on the corpus luteum, causing luteolysis or the degradation of the corpus luteum.
Abbreviation/Acronym:

  • PGF

Chemical formula:

  • C20H34O5
  • See also:

    Related term(s):

  • Prostaglandin f2a tromethamine
  • Prostaglandin-f synthase


    You will also like...

    Plant Water Regulation
    Plant Water Regulation

    Plants need to regulate water in order to stay upright and structurally stable. Find out the different evolutionary adap..

    Nephrolepis exaltata
    Vascular Plants: Ferns and Relatives

    Ferns and their relatives are vascular plants, meaning they have xylem and phloem tissues. Because of the presence of va..

    Oligodendrocyte and Schwann cell
    The Central Nervous System

    Myelin sheath is essential for a faster conductivity of signals. Know more about this feature of some neurons in the Cen..

    Lake Wakatipu, New Zealand
    New Zealand’s Unique Geographical History

    Explore why New Zealand has such unique flora and fauna, and learn why long periods of geographical isolation. This less..

    Still Water Animals
    Still Water Animals

    Animals living in aquatic habitats have diversified and evolved through time. They eventually occupy ecological niches a..

    Early Earth
    The Origins of Life

    This tutorial digs into the past to investigate the origins of life. The section is split into geological periods in the..