Dictionary > Definitive host

Definitive host

Definitive host
n., plural: definitive hosts
[dɪˈfɪn.ɪt.ɪv hoʊst]
Definition: the host where the sexual phase of the parasite’s life cycle occurs

Different Biological Relationships

The biological world is interconnected whether we notice it or not. All the life forms depend upon each other to run this biosphere in a well-balanced way. Different types of biological relationships exist in our biosphere, like mutualism, commensalism, amensalism, parasitism, competition, predation, co-occurrence (neutralism), etc. Have a look at the table below to gain basic insights into how two different species interact in these relationships respectively.

gain vs harm between two species in symbiosis
Figure 1: Species 1 and Species 2 are the two species that come together in the above-listed ecological relationships. (+) denotes benefit, (-) denotes harm and 0 denotes no effect to/on the species. Image Source: Akanksha Saxena of Biology Online

All these different types of ecological and symbiotic relationships help organisms survive in their respective niches. Niche is a physical dimension space that a biological life form occupies. To aid the species continuation, biological organisms produce more of their kind via reproduction. Throughout their lives, these organisms have various requirements like food, shelter, protection, reserve fund for the future, etc. So, the question that arises is “who takes care of these requirements?”

In mutualistic, commensalistic, and parasitic relationships, the hosts play some very vital roles that help in the sustenance of species. A host is “a harboring organism that provides all the hospitality services to a guest organism”. The host fulfills all the basic requirements of food, shelter, protection, reserve fund for future, etc of the guest organism/s.

The hosts are basically of five types. Before moving on to our topic of “definitive host” and answering the big question “what is a definitive host”, let’s have a look at the illustration below and understand the different host types.

types of hosts and definitions
Figure 2: There are majorly 5 types of hosts namely primary host (definitive host), secondary host, paratenic host, accidental host and reservoir host. Among these, primary hosts i.e., “definitive hosts” are of our prime concern in this article. Source: Akanksha Saxena of Biology Online

Parasite-Host Relationships

While a host is indispensable in all these relationships like mutualistic, commensalistic, and parasitic, we talk of two hosts- primary (definitive hosts) and secondary (intermediate hosts) in light of “parasitic relationships” only. A parasite-host relationship is a unique one as its “co-evolving”. By co-evolution, we mean that for every new adaptation that the host acquires to escape the parasite’s presence, the parasite also develops a “reciprocal or antagonistic” adaptation and co-evolves down the evolutionary timelines. This type of coevolution helps the parasite to develop a “consumer-resource interaction” with the host.

A parasite-host interaction is characterized by:

  1. Parasites in essence do not kill the host in a go (as opposed to predation where predators could eventually kill the prey); they extract and suck the nutrition out of the host as they live on/in them. This obviously harms the host.
  2. The hosts are typically bigger in size than parasites.
  3. The host’s fitness is reduced by the parasite.
  4. Parasites tend to increase their own fitness. They do so by feeding and extracting maximum nutrition out of the host’s body. Another way by which parasites increase their fitness is by taking assistance from a secondary host. Many parasites involve a secondary host in their life cycles to hop from one primary/definitive host to another.
  5. Some parasites involve 2 types of hosts in their life cycles, namely:
    • Primary (Definitive hosts)
    • Secondary (Intermediate hosts)
  6. Accordingly, the life cycles of parasites are of 2 types, namely:
    • Direct life cycles: Only one definitive host is involved in these life cycles of parasites.
    • Indirect life cycles: Two types of hosts are involved (definitive and intermediate) in these life cycles of parasites.
  7. Since parasites continuously have close interactions with other species, they tend to become “vectors” of many disease-causing pathogens and bring serious health implications to a variety of living organisms.

To learn more about the differences between these 2 hosts and the medical definition of the definitive host and intermediate host, look at the table below.

Table 1: Differences Between Definitive Host and Intermediate Host

Definitive Host Intermediate Host
It is that host that harbors the sexually-active phases of the parasite. It is that host that harbors the non-sexual (reproductively/sexually immature) phases of the parasite.
Also called the “primary” host. Also called the “secondary” host.
Site of sexual reproduction for the parasite. (So, if asked, a definitive host harbors which stage of a parasite… it’s the sexually-mature adult stage!) Site of asexual reproduction for the parasite
Parasite spends a longer duration of its life cycle in this host. Parasite spends a shorter/transient duration of its life cycle in this host.
Parasites’ gamete fusion and zygote formation happen in this host. Parasites’ sexual differentiation happens in this host.
a) Plasmodium is a malarial parasite causing malaria.
Definitive Host of Plasmodium= Female Anopheles mosquito
Intermediate Host of Plasmodium = Humans
b) Dirofilaria immitis is a heartworm parasite causing dirofilariasis.
Definitive Host= Dog
Intermediate Host= Mosquito
c) Wuchereria bancrofti, Brugia timori, and Brugia malayi are nematode parasites causing lymphatic filariasis.
Definitive Host= Humans
Intermediate Host= Mosquito


Definitive Host Definition

Biology/Microbiology/Parasitology definition:
A definitive host is a biological organism in whose body a parasite sexually multiplies and completes its life cycle. Reaching this sexual maturity is very important for the continuation of the parasite’s species. For example, human tapeworm makes use of humans as its definitive host. Synonym: primary host; final host. Compare: intermediate host

Now that we know how to define a definitive host, let’s look at some common examples and the diseases associated with the parasite harboring in the host’s body.



Definitive Host Examples

Some examples of definitive hosts are:

Table 2: Different parasites, their diseases, and definitive hosts

Parasite Disease caused Definitive Host
Plasmodium (P. falciparum, P. vivax, P. ovale and P. malariae.) Malaria in humans Female Anopheles mosquito
Dog heartworm (Dirofilaria immitis) Pulmonary Dirofilariasis in humans Domestic dogs, jackals, wolves
Dirofilaria tenuis, Dirofilaria repens Subcutaneous dirofilariasis in humans Only natural host for D. tenuis: raccoons
Hosts of D. repens: Wild and domestic canids
Wuchereria bancrofti, Brugia timori, Brugia malayi Lymphatic filariasis in humans Humans
Chinese or oriental liver fluke (Clonorchis sinensis) and Opisthorchis viverrini, Opisthorchis felineus Clonorchiasis in humans Humans, dogs, cats, other piscivorous mammals
Tapeworm (Taenia solium, Taenia saginata, Taenia asiatica) Taeniasis in humans Humans
Blood trematodes (Schistosoma mansoni, Schistosoma haematobium, Schistosoma japonicum) Schistosomiasis in humans S. mansoni: Only humans
S. japonicum: Cattle, horse, cats, dogs
Toxoplasma gondii Toxoplasmosis in humans, cats, cattle, animals bred for human diet/consumption (livestock) Domestic cats and their relatives
Trypanosoma cruzi, Trypanosoma gambiense, Trypanosoma rhodesiense Trypanosomiasis/Sleeping Sickness
T. cruzi– American Trypanosomiasis
T. gambiense– West African sleeping sickness (chronic)
T. rhodesiense– East African sleeping sickness (acute)
Mammals (humans)


life cycle of Plasmodium spp.
Figure 3: The life cycle of Plasmodium spp. is one of the most fascinating displays of natural abilities in the biological world. Even after having so many life stages like sporozoites, schizonts, merozoites, hypnozoites (in some species), gametocytes (micro-and macro-), zygotes, ookinetes, oocysts, back to sporozoites, the parasite doesn’t cause any harm to its “definitive host- the mosquito”!!
While on the other side, according to WHO, the parasite killed nearly 409,000 of its intermediate hosts- “the humans” in 2019. Image Credit: CDC.gov


Dirofilaria immitis life cycle
Figure 4: Pulmonary dirofilariasis is caused by a dog heartworm Dirofilaria immitis in humans. The vectors for this parasite are mosquitos and the definitive hosts are dogs. When a mosquito carrying this parasite bites a human, the parasite finds its way to the human lungs. It causes lesions, infarcts, and necrosis in the small-caliber vessels of the lungs (pulmonary vessels). Image Credit: CDC.gov


Chinese liverfluke life cycle
Figure 5: Clonorchiasis or the “raw fish infection” in humans is caused by the Chinese liver fluke. The sexual stages and life cycle of this parasite are incomplete without the definitive host which is “human beings”. Most cases are reported from Far East Asia, which is actually endemic to clonorchiasis. To prevent the disease, it’s recommended to eat properly cooked fish, not just salted, smoked ones! Image Credit: Stanford University.


Toxoplasma gondii life cycle
Figure 6: The flowchart depicts the life cycle of Toxoplasma gondii. The interesting thing about this parasite is that it can cross the placental barrier. So, if a mother becomes infected, there are nearly 50% chances that the fetus might also get toxoplasmosis. It makes this disease of significant interest in epidemiology. Image Credit: The Veterinary Nurse


Interesting Fact

Can you imagine that a “parasite” can hypnotize its “host” for its transmission and multiplication to such an extent that the host becomes careless enough to get hunted down by its predator???

  • Parasite: Toxoplasma gondii
  • Intermediate Host whose behavior is altered: Rodents
  • Predator: Definitive Host – Cats

Changes in rodents upon ingesting T.gondii:

  1. Rodents become careless, more extroverted and their inhibitions around cats are lost.
  2. Rodents stop turning on their defense mechanisms upon encounters with cats.
  3. Rodents start getting attracted by feline’s urine and its smell.

Yes, there are some “BEHAVIOUR-ALTERING PARASITES” that can manipulate and modify the behavior of their (intermediate) hosts to such an extent that tendencies of intermediate hosts are modified. Thereafter, the chances of the intermediate hosts being eaten by the definitive host (predator) increase in such cases. And who’s the culprit? The parasite!

In many of the parasites which are “trophically-transmitted”, meaning transmitted via food/ingestion, parasites possess special behavior-altering mechanisms to amp up their chances to reach their definitive hosts. This happens by manipulating and modifying the general decision-making abilities, controlling abilities, neurochemical signaling, and communication, behavioral mechanisms, hijacking of the host’s CNS (central nervous system), etc. For the sexual maturity of any parasite, reaching its final definitive host is very important. Thus, the intermediate host is hypnotized and made to follow all the directions that increase the chances of the parasite’s transmission to the definitive host, along with the surety of its safety and security all throughout the journey!

And, this mechanism is sometimes referred to as “Increased trophic facilitation or Parasite increased trophic transmission”.

(Source: Berdoy, M. et al, 2000, Boillat M., 2020)

Toxoplasma gondii infection diagram
In order to reach its definitive host at any cost, Toxoplasma gondii manipulates its intermediate host (rodents) in such a way that they lose all their fear/anxiety/aversion/defense mechanisms against their predators (cats). Cats are the definitive hosts of this parasite (Toxoplasma gondii) and upon ingesting these infected rodents, the cat’s body becomes the “breeding ground” of the parasite. Source: Boillat M., 2020.


Try to answer the quiz below to check what you have learned so far about definitive hosts.


Choose the best answer. 

1. Which of the following depicts a "definitive" host?

2. The definitive host in the life cycle of Wuchereria bancrofti (causative agent of lymphatic filariasis)

3. The definitive host in the life cycle of malarial parasite, Plasmodium vivax

4. The definitive host in the life cycle of Toxoplasma gondii

5. The stage of Plasmodium when it enters or infects its definitive host

Send Your Results (Optional)

Your Name
To Email


  • Vlachou, D., Schlegelmilch, T., Runn, E., Mendes, A., & Kafatos, F. C. (2006). The developmental migration of Plasmodium in mosquitoes. Current opinion in genetics & development, 16(4), 384-391.
  • Orihel, T. C. (1961). Morphology of the larval stages of Dirofilaria immitis in the dog. The Journal of parasitology, 47(2), 251-262.
  • Jordan, P. (1952). Wuchereria bancrofti. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46(2), 207-208.
  • Edeson, J. F. B., & Wilson, T. (1964). The epidemiology of filariasis due to Wuchereria bancrofti and Brugia malayi. Annual Review of Entomology, 9(1), 245-268.
  • Hong, S. T. (2003). Clonorchis sinensis. In International handbook of foodborne pathogens (pp. 601-612). CRC Press.
  • Berdoy, M., Webster, J. P., & Macdonald, D. W. (2000). Fatal attraction in rats infected with Toxoplasma gondii. Proceedings. Biological Sciences, 267(1452), 1591–1594. https://doi.org/10.1098/rspb.2000.1182
  • Lindová, Jitka; Příplatová, Lenka; Flegr, Jaroslav (2012). “Higher Extraversion and Lower Conscientiousness in Humans Infected with Toxoplasma“. European Journal of Personality. 26 (3): 285–291. doi:10.1002/per.838
  • Duvaux-Miret, O., Stefano, G. B., Smith, E. M., Dissous, C., & Capron, A. (1992). Immunosuppression in the definitive and intermediate hosts of the human parasite Schistosoma mansoni by release of immunoactive neuropeptides. Proceedings of the National Academy of Sciences, 89(2), 778-781.
  • World Health Organization: WHO. (2021, October 28). Malaria. World Health Organization: WHO. https://www.who.int/news-room/fact-sheets/detail/malaria
  • Tyler, K. M., & Engman, D. M. (2001). The life cycle of Trypanosoma cruzi revisited. International journal for parasitology, 31(5-6), 472-481.
  • Boillat, M., Hammoudi, P. M., Dogga, S. K., Pagès, S., Goubran, M., Rodriguez, I., & Soldati-Favre, D. (2020). Neuroinflammation-Associated Aspecific Manipulation of Mouse Predator Fear by Toxoplasma gondii. Cell reports, 30(2), 320–334.e6. https://doi.org/10.1016/j.celrep.2019.12.019

©BiologyOnline.com. Content provided and moderated by Biology Online Editors.

You will also like...

Salmon jumping upstream in the river
Lotic Communities & Animals

A running water environment offers numerous microhabitats for many types of animals. Similar to plants, animals in lotic..

"Opabinia regalis"
The Evolutionary Development of Multicellular Organisms

Multicellular organisms evolved. The first ones were likely in the form of sponges. Multicellularity led to the evolutio..

Cell Biology
Cell Biology

The cell is defined as the fundamental, functional unit of life. Some organisms are comprised of only one cell whereas o..

Sigmund Freud and Carl Gustav Jung
Sigmund Freud and Carl Gustav Jung

In this tutorial, the works of Carl Gustav Jung and Sigmund Freud are described. Both of them actively pursued the way h..

Biological Cell schematic diagram
Biological Cell Introduction

It only takes one biological cell to create an organism. A single cell is able to keep itself functional through its 'mi..

IQ, Creativity and Learning
IQ, Creativity and Learning

Human intelligence provided the means to utilize abstract ideas and implement reasoning. This tutorial takes a further l..

Related Articles...

No related articles found

See all Related Topics