Dictionary > Demecolcine

Demecolcine

Definition
noun
(cytogenetics) A cytotoxic alkaloid isolated from Colchicum autumnale, and is used as an antineoplast agent
Supplement
Demecolcine is an alkaloid that is derived from Colchicum autumnale (commonly known as autumn crocus plant). It is used in cytogenetics laboratory, particularly in chromosome analysis. It is capable of arresting cells in mid-metaphase of cell division.
Chemically, it is similar to colchicine. The difference between demecolcine and colchicine is the presence of methyl group rather than the acetyl group on the amino moiety. Demecolcine is also less toxic than colchicine. Nevertheless, both demecolcine and colchicine exert similar effect on mitosis. Demecolcine is capable of depolymerizing microtubules. In cytologenetics laboratory, it is used to arrest cells in metaphase, and allow cell harvest for karyotyping. The longer the cells are exposed to demecolcine the more cells arrested in metaphase may be collected. 2
Demecolcine is also used as a pharmacological agent in chemotherapy. It improves the efficacy of cancer radiotheraphy in such a way that it synchronizes tumor cells at metaphase, which is a radiosensitive stage of the cell cycle.1
IUPAC name: (S)-1,2,3,10-Tetramethoxy-7-methylamino-6,7-dihydro-5H-benzoaheptalen-9-one
Molecular formula: C21H25NO5
Synonym(s):

See also:

  • cytogenetics
  • depolymerization
  • microtubule
  • spindle fiber
  • metaphase
  • cell division
  • karyotyping
  • mitosis
  • Reference(s):

    1Wikipedia. ://en.wikipedia.org/wiki/Demecolcine Link

    2Gersen, M. and Keagle, M. (2013). The principles of clinical cytogenetics. N.Y.: Springer Science & Business Media.


    You will also like...

    Biological Viruses
    Biological Viruses

    Viruses possess both living and non-living characteristics. This unique feature distinguishes them from other organisms...

    Homo Species
    The Homo Species

    The evolution of the species of the genus "Homo" led to the emergence of modern humans. Find out more about human evolut..

    Buttress roots
    Roots

    This study guide tackles plant roots in greater detail. It delves into the development of plant roots, the root structur..

    Chromosome Mutations
    Chromosome Mutations

    Mutations can also influence the phenotype of an organism. This tutorial looks at the effects of chromosomal mutations, ..

    Genetic engineering
    Genetic Engineering Advantages & Disadvantages

    This tutorial presents the benefits and the possible adverse eventualities of genetic engineering. Know more about this ..

    Peppered moth ("Biston betularia") melanic and light form
    Examples of Natural Selection

    Darwin's Finches are an example of natural selection in action. They are an excellent example of the way species' gene p..

    Related Articles...

    No related articles found

    See all Related Topics