Dictionary > Diplotene


The late stage of prophase I of meiosis I in which homologous chromosome pairs begin to separate and move away from one another except at chiasmata.
Meiosis is form of cell division that gives rise to genetically diverse sex cells or gametes. It is comprised to two successive nuclear divisions namely meiosis I and meiosis II. Meiosis I is comprised of four stages: prophase I, metaphase I, anaphase I, and telophase I. Prophase I is the first stage and consists of the following sub-stages: leptotene, zygotene, pachytene, diplotene and diakinesis.
Diplotene is the next stage after pachytene. Prior to diplotene stage, the paired homologous chromosomes (called tetrad or bivalent) became shorter and thicker, and the sister chromatids became more distinct. A zipper-like structure called synaptonemal complex that formed between paired chromosomes in the earlier stage degrades at diplotene stage resulting in the homologous chromosomes to separate a bit. Homologous recombination and chromosomal crossovers between nonsister chromatids at chiasmata took place prior to diplotene stage. Homologous chromosomes remained paired and tightly bound at chiasmata at this point.
In human oogenesis, the oocytes are arrested in this stage and would resume through the remaining stages of meiosis at puberty. This stage is referred to as the dictyotene stage or dictyate.
Word origin: from Greek words meaning “two threads”

  • diplonema

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