Dictionary > Erwin Chargaff

Erwin Chargaff

Quick Info
(person) A biochemist known for his proposed Chargaff’s rules that led to the discovery of the double helical structure of DNA
Supplement
Erwin Chargaff was an Austro-Hungarian biochemist and a professor of biochemistry in Columbia University. He is known for his proposed rules that are referred to now as Chargaf’s rules. Accordingly, a natural DNA would have the same number of guanine units and cytosine units. Likewise, the number of adenine units would equal the number of thymine units. Thus, this would implicate base pairing in DNA. This rule of Chargaff disproved the formerly accepted hypothesis called tetranucleotide hypothesis. In tetranucleotide hypothesis, it stated that DNA was comprised of a number of repeats of guanine, adenine, cytosine, and thymine, and variations in the equimolar base ratios were due to experimental error. Chargaff refuted it and proved them wrong through his experimentation that made use of paper chromatography and ultraviolet spectrophotometer. He later met with Francis Crick and James Watson to explain what he found in his research. Many believed that this first rule of Chargaff helped the research team of Watson and Crick to conclude the double helix structure of DNA. The second rule is that the amounts of adenine, thymine, guanine, and cytosine would vary from one species to another, implicating that the genetic material is DNA rather than protein.
See also:


You will also like...

Kidneys
Kidneys and Regulation of Water and Inorganic Ions

The kidneys are responsible for the regulation of water and inorganic ions. Read this tutorial to learn about the differ..

Birth Control and Contraception
Birth Control and Contraception

Different pregnancy and birth control and contraception strategies are described. Read this tutorial to learn each of th..

Cells in different stages of meiosis
Meiosis – The Genetics of Reproduction

Meiosis is a form of cell division that creates gametes. It is comprised of two divisions that in the end, the resulting..

sponge
Primitive Animals

Life, as we know it today, is presumed to have started in the sea and many of them were likely eukaryotic animal-like or..

Crossing Over and Genetic Diversity
Inheritance and Probability

Gregor Mendel, an Austrian monk, is most famous in this field for his study of the phenotype of pea plants, including ..

Water Cycle
The Water Cycle

The water cycle (also referred to as the hydrological cycle) is a system of continuous transfer of water from the air, s..

Related Articles...

No related articles found

See all Related Topics