Dictionary > Fibroblast

Fibroblast

Definition
noun, plural: fibroblasts
Cell of connective tissue that produces and secretes fibers (e.g. collagens, reticular and elastic fibers) and glycosaminoglycans (a ground substance constituent), and thus, functions in the maintenance of the extracellular matrix (especially during wound healing or tissue repair), and in providing a structural framework for many tissues
Supplement
Fibroblasts are a biological cell that produces and secretes fibers (e.g. collagens, reticular and elastic fibers) and certain ground substance constituents (e.g. glycosaminoglycans). Thus, they are responsible for the production of the precursors and the maintenance of the extracellular matrix. Their secretions also provide structural framework for many biological tissues of animals.
In animals, the connective tissue is one of the major types of tissues and its main functions are to provide structural support and to connect tissues and organs. The fibroblasts are just one of the various cellular elements of the connective tissues. Other connective tissue cell types are adipocytes and blood cells (such as macrophages, mast cells, etc.). Nevertheless, the fibroblasts are regarded as the most common connective tissue cell type.
The fibroblasts have different shapes. They can be stellate, fusiform, or spindle-shaped. In general, though, fibroblasts have branched cytoplasm and an elliptical nucleus with two or more nucleoli. Endoplasmic reticula are abundant in active fibroblasts. Metabolically inactive fibroblasts are referred to as fibrocytes.
Apart from maintaining the extracellular matrix, the fibroblasts are also involved in triggering inflammation and immune response. In the presence of invading microbes, they present receptors on their surface to initiate chemokine synthesis, which in turn, incites inflammation and immune response.
See also:

Related term(s):

  • Fibroblast activation protein
  • Fibroblast growth factor 4
  • Fibroblast growth factor receptor-like embryonic k
  • Fibroblast growth factors
  • Fibroblast interferon
  • Related form(s):

    • fibroblastic (adjective, of, pertaining to, relating to, characterized by, or resembling a fibroblast)


    You will also like...

    Disturbance on a still water
    Abiotic Factors – Water Conditions

    A still body of water may be disturbed by a variety of factors. One of them is wind. In fact, it is considered as the pr..

    DNA molecule
    Genetic Control – On and Off Genes

    Genes are the blueprint of our bodies, a blueprint that creates a variety of proteins essential to any organism's surviv..

    Still Water Community Plants
    Still Water Community Plants

    This tutorial looks at the adaptations of freshwater plants for them to thrive in still water habitats. Familiarize your..

    Growth Patterns
    Growth Patterns

    This tutorial describes the sigmoid curve, annual plant growth, tree growth, human growth, and insect growth as the grow..

    Angle Oak Tree
    Seed Plants

    Seed plants are vascular plants. They differ from the other vascular plants in producing seeds that germinate into a new..

    Schematic diagram of bacterial lactose operon
    Gene Action – Operon Hypothesis

    Learn how the way genes control and determine every aspect of the body. This lesson uses lac operon as an example. ..

    ..