Dictionary > Glycogenesis


The metabolic process of producing glycogen from glucose for storage mainly in liver and muscle cells in response to high glucose level in the bloodstream
In humans and many other animals, glycogenesis is the process in which glycogen is produced to be stored mainly in liver and muscle cells. Short polymers of glucose are converted into long polymers. The body does not directly utilize exogenous glucose, i.e. from a carbohydrate-containing meal. Instead, the body stores glucose into glycogen within cells through the process of glycogenesis. And when the body requires metabolic energy, glycogen is broken down into glucose subunits through the process of glycogenolysis. Thus, glycogenesis is the opposite process of glycogenolysis.
Glycogenesis begins in glucose that is phosphorylated to become glucose-6-phosphate through the enzymes hexokinase in muscle and glucokinase in liver. The next steps of the process are as follows:

  • Glucose-6-phosphate (by phosphoglucomutase) –> Glucose-1- phosphate
  • Glucose-1-phosphate + UTP (by UDP-glucose pyrophosphorylase) –> UDP-glucose + PPi
  • PPi + H2O –> 2Pi
  • UDP-glucose + Glycogenn (by glycogen synthase) –> Glycogenn+1 + UDP
  • UDP + ATP –> UTP + ADP

When the chain lengthens to a minimum of 11 residues, the branching enzyme amylo-1,4 to 1,6-transglucosidase transfers a part of the chain to a neighboring chain, thus, establishes a branching point in the molecule.1

See also:

  • glycogen
  • glucose
  • insulin
  • Reference(s):

    1 Naik, P. (2015). Biochemistry. JP Medical Ltd. p.182-183.

    You will also like...

    Angle Oak Tree
    Seed Plants

    Seed plants are vascular plants. They differ from the other vascular plants in producing seeds that germinate into a new..

    Freshwater lake ecosystem
    Freshwater Producers and Consumers

    Freshwater ecosystem is comprised of four major constituents, namely elements and compounds, plants, consumers, and deco..

    Golgi apparatus (3-D illustration)
    Role of Golgi Apparatus & Endoplasmic Reticulum in Protein Synthesis

    The endoplasmic reticulum and Golgi apparatus are the organelles involved in the translation step of protein synthesis a..

    Pink Lotus plant on a pond
    Freshwater Lentic Communities & Animals

    This tutorial looks at some of the communities in freshwater lentic habitats. For instance, symbiosis occurs in a commun..

    Genetic engineering
    Genetic Engineering Advantages & Disadvantages

    This tutorial presents the benefits and the possible adverse eventualities of genetic engineering. Know more about this ..

    Disturbance on a still water
    Abiotic Factors – Water Conditions

    A still body of water may be disturbed by a variety of factors. One of them is wind. In fact, it is considered as the pr..