Dictionary > Isopeptide bond

Isopeptide bond

Definition
noun, plural: isopeptide bonds
A peptide bond formed between a carboxyl group of one amino acid and an amino group of another at position other than alpha
Supplement
An isopeptide bond is the type of peptide bond that forms between the between the carboxyl group and an amino group of joining amino acids where at least one of them is part of the side chain. It may also form between the gamma-carboxamide group of glutamine and the primary amine of certain amino acids.
It is distinct from the eupeptide bond (also referred to simply as peptide bond). A eupeptide bond, in contrast, is an amide type of chemical bond that forms between the carbon 1 of alpha-amino acid and nitrogen 2 of another amino acid.
The isopeptide bond is less common compared with eupeptide bonds. The eupeptide bonds are the more common type.
An example of a peptide with an isopeptide bond is the glutathione. The glutathione has an isopeptide bond between the side chain of a glutamate residue and the amino group of a cysteine residue.
Ubiquitin is also another example. It is a protein that forms a complex with another protein by forming an isopeptide bond between its C-terminal of the glycine residue and the lysine side chain of the substrate protein.
The peptides containing isopeptide bonds are often associated with biosignaling and biostructural functions.
Compare:

Related term(s):


You will also like...

Biosecurity and Biocontrol
Biosecurity and Biocontrol

This lesson explores the impact of biosecurity threats, and why they need to be identified and managed. Examples to incl..

Direct and indirect physiologic effects of growth hormone
Animal Growth Hormones

Hormones are produced in the endocrine glands of animals. The pituitary gland and hypothalamus are the most impor..

Regulation of Biological Systems
Regulation of Biological Systems

Regulation of Biological Systems tutorials are focused on the modulation of biological systems from cell to population l..

Fossil trilobite imprint in the sediment
Insects

There are more species of insects than any other species combined. This surely illustrates that insects have the selecti..

Selective Breeding
Selective Breeding

Gregor Mendel's studies into Monohybrid and Dihybrid crossing and Charles Darwin's study of evolution and natural select..

Biological Energy
ATP & ADP – Biological Energy

ATP is the energy source that is typically used by an organism in its daily activities. The name is based on its structu..