Dictionary > Isopeptide bond

Isopeptide bond

Definition
noun, plural: isopeptide bonds
A peptide bond formed between a carboxyl group of one amino acid and an amino group of another at position other than alpha
Supplement
An isopeptide bond is the type of peptide bond that forms between the between the carboxyl group and an amino group of joining amino acids where at least one of them is part of the side chain. It may also form between the gamma-carboxamide group of glutamine and the primary amine of certain amino acids.
It is distinct from the eupeptide bond (also referred to simply as peptide bond). A eupeptide bond, in contrast, is an amide type of chemical bond that forms between the carbon 1 of alpha-amino acid and nitrogen 2 of another amino acid.
The isopeptide bond is less common compared with eupeptide bonds. The eupeptide bonds are the more common type.
An example of a peptide with an isopeptide bond is the glutathione. The glutathione has an isopeptide bond between the side chain of a glutamate residue and the amino group of a cysteine residue.
Ubiquitin is also another example. It is a protein that forms a complex with another protein by forming an isopeptide bond between its C-terminal of the glycine residue and the lysine side chain of the substrate protein.
The peptides containing isopeptide bonds are often associated with biosignaling and biostructural functions.
Compare:

  • eupeptide bond

Related term(s):


You will also like...

3D rendering of an antibody
Passive and Active Types of Immunity

Lymphocytes are a type of white blood cell capable of producing a specific immune response to unique antigens. In thi..

Gibberellins and Gibberellic Acid
Gibberellins and Gibberellic Acid

This tutorial describes the role of gibberellin family in plants. Find out the effects of gibberellin on plant growth an..

Developmental Biology
Developmental Biology

Developmental biology is a biological science that is primarily concerned with how a living thing grows and attains matu..

Muscle
Muscle

Muscle cells are specialized to generate force and movement. Learn about the different types of muscle tissues in this t..

An artistic depiction of a human embryo
Growth and Development of a Human Baby

Upon fertilization, a zygote forms and develops into an embryo. This tutorial elaborates on the growth and development f..

Thermographic image of face and neck
Regulation of Organic Metabolism, Growth and Energy Balance

The human body is capable of regulating growth and energy balance through various feedback mechanisms. Get to know the e..