Dictionary > Major histocompatibility complex

Major histocompatibility complex

Definition
noun
A cluster of genes on a particular chromosome that specify major histocompatibility antigens
Supplement
Major histocompatibility complex (acronym: MHC) refers to a cluster of genes that are located next to or near each other on a particular chromosome. These genes specify for major histocompatibility antigens, which are mostly glycoproteins expressed on the cell surface.
The expression of MHC molecules on the cell surface accounts for histocompatibility, i.e. tissue compatibility. In other words, the cells from one individual can be distinguished from the cells of another based on the MHC molecules when the MHC genes are expressed. This is essential as MHC molecules enable the immune system to distinguish self from non-self (foreign) cells. For instance, the cell displays on its cell surface a fraction of a protein (called epitope), which can either be self-antigens (i.e. major histocompatibility antigens) or non-self antigens. The non-self antigens are epitopes from destroyed pathogens.
MHC molecules are also essential as they determine the compatibility of donors for organ transplants.
MHC includes the human leukocyte antigen (HLA) in humans, H-2 complex in mice, RLA in rabbits, RT 1 in rats, DLA in dogs, SLA in pigs, etc.
Abbreviation/Acronym:

  • MHC

See also:

  • human leukocyte antigen (HLA)
  • Related term(s):

    • major histocompatibility complex I
    • major histocompatibility complex II
    • major histocompatibility complex III


    You will also like...

    squirrel
    Animal Water Regulation

    Animals adapt to their environment in aspects of anatomy, physiology, and behavior. This tutorial will help you understa..

    Plant Water Regulation
    Plant Water Regulation

    Plants need to regulate water in order to stay upright and structurally stable. Find out the different evolutionary adap..

    Water Cycle
    The Water Cycle

    The water cycle (also referred to as the hydrological cycle) is a system of continuous transfer of water from the air, s..

    Adaptation Tutorial
    Adaptation Tutorial

    Adaptation, in biology and ecology, refers to the process or trait through which organisms or the populations in a habit..

    Plant biology
    Plant Biology

    Plantlife can be studied at a variety of levels, from the molecular, genetic and biochemical level through organelles, c..

    Early Earth
    The Origins of Life

    This tutorial digs into the past to investigate the origins of life. The section is split into geological periods in the..

    Related Articles...

    No related articles found

    See all Related Topics