Dictionary > Monoblast

Monoblast

Definition
noun, plural: monoblasts
A precursor cell that gives rise to a promonocyte
Supplement
Hematopoiesis is the process of forming new blood cellular elements in vertebrates. It begins with a multipotent stem cell, a hemocytoblast, which gives rise to a common myeloid progenitor cell (CMP). The CMP, in turn, gives rise to granulocyte-monocyte colony forming units (CFU-GM), also called granulocyte-macrophage progenitor. The CFU-GM may partially differentiate into CFU-G (precursor in myelocyte-granulocyte series) or CFU-M (precursor in monocyte-macrophage series). The CFU-GM serves as the precursor for monoblasts and myeloblasts.
The monoblast is a committed progenitor cell that gives rise to a promonocyte. Its size ranges from 12 to 20 µm in diameter. It is considered as the largest blast in the hematopoietic cell lines. Its nucleus is round to oval in shape and often centrally located. It usually has one nucleolus. The cytoplasm is basophilic. When stained, it will have a slightly lighter bluish color. The nuclear to cytoplasm ratio is 4:1 to 3:1.
The monoblasts are the first developmental stage of the monocyte series and are found in the bone marrow.
See also:

Related form(s):

  • monoblastic (adjective, of, pertaining to, or relating to a monoblast)


  • You will also like...

    squirrel
    Animal Water Regulation

    Animals adapt to their environment in aspects of anatomy, physiology, and behavior. This tutorial will help you understa..

    Plant Water Regulation
    Plant Water Regulation

    Plants need to regulate water in order to stay upright and structurally stable. Find out the different evolutionary adap..

    Water Cycle
    The Water Cycle

    The water cycle (also referred to as the hydrological cycle) is a system of continuous transfer of water from the air, s..

    Adaptation Tutorial
    Adaptation Tutorial

    Adaptation, in biology and ecology, refers to the process or trait through which organisms or the populations in a habit..

    Plant biology
    Plant Biology

    Plantlife can be studied at a variety of levels, from the molecular, genetic and biochemical level through organelles, c..

    Early Earth
    The Origins of Life

    This tutorial digs into the past to investigate the origins of life. The section is split into geological periods in the..

    Related Articles...

    No related articles found

    See all Related Topics