Dictionary > Polygenic disease

Polygenic disease

Definition
noun
An inherited disease determined by the effects of the simultaneous action or interaction of several genes
Supplement
Polygenic disease (or polygenic disorder) results from the effects of the combined action or interaction of multiple genes. More than one gene is associated with a polygenic disease or disorder. Because of the complexity of genetic interactions, it does not follow a pattern the same way a monogenic disease does. In humans, though, polygenic conditions occur more frequently than monogenic diseases.
Apart from the multiple genes involved, non-genetic factors may also play a role in the manifestation of the disease. For instance, type 2 diabetes is a disease characterized by the presence of excessive glucose levels circulating in blood and symptoms such as polyphagia, polyuria, and polydipsia. It is a polygenic disease having involved with more than one gene, i.e. more than 36 genes (e.g. TCF7L2 allele). These genes increase the risk of developing diabetes. Many of these genes are linked to beta cell functions. Other factors associated with the contraction of diabetes include non-genetic factors, e.g. lifestyle and diet.
Other examples of polygenic conditions are coronary heart disease, hypertension, autoimmune diseases, cancers, obesity, and atherosclerosis.
Compare:

See also:


You will also like...

running freshwater community
Running Water Freshwater Community Factors

This tutorial noted some of the physical and chemical factors that provide the framework of a running water community in..

Disturbance on a still water
Abiotic Factors – Water Conditions

A still body of water may be disturbed by a variety of factors. One of them is wind. In fact, it is considered as the pr..

An artistic depiction of a human embryo
Growth and Development of a Human Baby

Upon fertilization, a zygote forms and develops into an embryo. This tutorial elaborates on the growth and development f..

Human perception in action
Human Perception – Neurology

This tutorial investigates perception as two people can interpret the same thing differently. Know more about human perc..

temperature - abiotic factor
Abiotic and Biotic Factors

This tutorial deals with the abiotic factors of the freshwater environment that determine what sort of life would be sui..

Sigmund Freud and Carl Gustav Jung
Sigmund Freud and Carl Gustav Jung

In this tutorial, the works of Carl Gustav Jung and Sigmund Freud are described. Both of them actively pursued the way h..