Dictionary > Pribnow box

Pribnow box

Pribnow box –>
(Science: molecular biology) A region of dNA to which rNA polymerase binds before initiating the transcription of DNA into rNA.
The nucleotide at which transcription starts is designated -1 and nucleotides are numbered from this with negative numbers indicating upstream nucleotides and positive downstream nucleotides.
most bacterial promoters contain two consensus sequences that seem to be essential for the binding of the polymerase. The first, the pribnow box, is at about 10 and has the consensus sequence 5′ TATAAT 3′. The second, the 35 sequence, is centred about 35 and has the consensus sequence 5′ TTGACA 3′.
most factors that regulate gene transcription do so by binding at or near the promoter and affecting the initiation of transcription. Much less is known about eukaryote promoters, each of the three rNA polymerases has a different promoter.
rNA polymerase I recognises a single promoter for the precursor of rRNA.
rNA polymerase II, that transcribes all genes coding for polypeptides, recognises many thousands of promoters. most have the Goldberg Hogness or tATA box that is centred around position 25 and has the consensus sequence 5′ TATAAAA 3′. Several promoters have a cAAT box around 90 with the consensus sequence 5′ GGCCAATCT 3′. There is increasing evidence that all promoters for housekeeping genes contain multiple copies of a gC rich element that includes the sequence 5′ GGGC
GG 3′. Transcription by polymerase II is also affected by more distant elements known as enhancers.
rNA polymerase III synthesises 5s ribosomal RNA, all tRNAs and a number of small rNAs. The promoter for RNA polymerase III is located within the gene either as a single sequence, as in the 5s RNA gene or as two blocks, as in all tRNA genes.

You will also like...

Population Growth and Survivorship
Population Growth and Survivorship

This lesson looks at population attributes, regulation, and growth. It also covers population genetics, particularly gen..


Stems primarily provide plants structural support. This tutorial includes lectures on the external form of a woody twig ..

DNA molecule
Genetic Control – On and Off Genes

Genes are the blueprint of our bodies, a blueprint that creates a variety of proteins essential to any organism's surviv..

Energy pyramid
Freshwater Community Energy Relationships – Producers & Consumers

This tutorial looks at the relationship between organisms. It also explores how energy is passed on in the food chain an..

Origins of Life on Earth
Origins of Life on Earth

Earth was created around 4.5 billion years ago and life began not long after. Primitive life likely possessed the elemen..

Neurology of Illusions
Neurology of Illusions

Illusions are the perceptions and sensory data obtained from situations in which human error prevents us from seeing the..