Dictionary > Pribnow box

Pribnow box

Pribnow box –>
promoter
(Science: molecular biology) A region of dNA to which rNA polymerase binds before initiating the transcription of DNA into rNA.
The nucleotide at which transcription starts is designated -1 and nucleotides are numbered from this with negative numbers indicating upstream nucleotides and positive downstream nucleotides.
most bacterial promoters contain two consensus sequences that seem to be essential for the binding of the polymerase. The first, the pribnow box, is at about 10 and has the consensus sequence 5′ TATAAT 3′. The second, the 35 sequence, is centred about 35 and has the consensus sequence 5′ TTGACA 3′.
most factors that regulate gene transcription do so by binding at or near the promoter and affecting the initiation of transcription. Much less is known about eukaryote promoters, each of the three rNA polymerases has a different promoter.
rNA polymerase I recognises a single promoter for the precursor of rRNA.
rNA polymerase II, that transcribes all genes coding for polypeptides, recognises many thousands of promoters. most have the Goldberg Hogness or tATA box that is centred around position 25 and has the consensus sequence 5′ TATAAAA 3′. Several promoters have a cAAT box around 90 with the consensus sequence 5′ GGCCAATCT 3′. There is increasing evidence that all promoters for housekeeping genes contain multiple copies of a gC rich element that includes the sequence 5′ GGGC
731
GG 3′. Transcription by polymerase II is also affected by more distant elements known as enhancers.
rNA polymerase III synthesises 5s ribosomal RNA, all tRNAs and a number of small rNAs. The promoter for RNA polymerase III is located within the gene either as a single sequence, as in the 5s RNA gene or as two blocks, as in all tRNA genes.


You will also like...

Gene Pool and Speciation
The Gene Pool and Population Genetics

According to Charles Darwin's theory of natural selection, preferable genes are favored by nature in the gene pool, and ..

Early Earth
The Origins of Life

This tutorial digs into the past to investigate the origins of life. The section is split into geological periods in the..

A chart depicting Mendel's Law of Dominance
Mendel’s Law & Mendelian Genetics

One of Mendel’s law of inheritance is the “law of dominance”. Read this tutorial to know more about this form of i..

Homo Species
The Homo Species

The evolution of the species of the genus "Homo" led to the emergence of modern humans. Find out more about human evolut..

Selective Breeding
Selective Breeding

Gregor Mendel's studies into Monohybrid and Dihybrid crossing and Charles Darwin's study of evolution and natural select..

sponge
Primitive Animals

Life, as we know it today, is presumed to have started in the sea and many of them were likely eukaryotic animal-like or..