Dictionary > Hayflick phenomenon

Hayflick phenomenon

Definition
noun
The phenomenon characterized by the limited number of times a normal cell population would divide mitotically until it stops dividing and become senescent
Supplement
In 1961, the American anatomist Leonard Hayflick, together with the cytogeneticist Paul Moorhead, conducted series of experiments on normal culture fibroblast cells and showed that the cells had limited capacity to divide when the cells stopped dividing. They proposed three phases of cell culture, i.e. phase I, phase II, and phase III. Phase I is the primary culture. Phase II is the period when cells multiplied in culture. Phase III is that phase when the cells multiplied relatively slow and ultimately stopped dividing.1 Their proposition contested the popular assumption, which was the cells would be immortal as long as the appropriate conditions would be provided. They theorized that cells would have a limitation as to the number of times they would divide before entering senescence. This phenomenon is postulated to occur as a result of telomere shortening triggering DNA damage response.
Synonym(s):

  • replicative senescence
  • Hayflick limit
  • phase III phenomenon

See also:

  • senescence
  • Established cell line
  • Immortalization
  • Cell line
  • Cell death
  • Reference(s):

    1 Shay, J. W. and Wright, W. E. (October 2000). Hayflick, his limit, and cellular ageing. Nature Reviews Molecular Cell Biology 1: 72-76.


    You will also like...

    Ecological Research Measuring & Analysis
    Ecological Research: Measuring & Analysis

    This lesson is about the methods used for ecological research, such as quadrat and transect sampling, canopy fogging, an..

    Biological Cell schematic diagram
    Biological Cell Introduction

    It only takes one biological cell to create an organism. A single cell is able to keep itself functional through its 'mi..

    Mātauranga Māori and Science Collaboration
    Mātauranga Māori and Science

    Mātauranga Māori is the living knowledge system of the indigenous people of New Zealand, including the relationships t..

    Disturbance on a still water
    Abiotic Factors – Water Conditions

    A still body of water may be disturbed by a variety of factors. One of them is wind. In fact, it is considered as the pr..

    kinesin motor proteins transporting molecules across microtubules
    Movement of Molecules Across Cell Membranes

    Molecules move within the cell or from one cell to another through different strategies. Transport may be in the form of..

    Ploidy
    Polyploidy

    Humans are diploid creatures. This means that for every chromosome in the body, there is another one to match it. Howeve..

    Related Articles...

    No related articles found

    See all Related Topics