Dictionary > Hypomorphic mutation

Hypomorphic mutation

Definition
noun
(genetics) A type of mutation wherein the change in gene leads to the partial loss of the normal (wild-type) gene function, such as by reduced expression (of protein or RNA)
Supplement
Mutations involving recessive genes often results in the reduction or elimination of the gene function. When the function of the gene is completely eliminated the mutation is referred to as amorphic. But when the mutation leads to only a reduction in the gene function it is called hypomorphic. Thus, in the latter type of mutation, the function of the gene is not eliminated but reduced. Other types of mutations based on the effects on the phenotypes are antimorphic mutation, hypermorphic mutation, and neomorphic mutation. Both amorphic and hypomorphic mutations are associated with the loss of function due to a gene mutation. The other three, in contrast, are related to the “gain of function” of the gene. The terms were coined by the American geneticist, Hermann J. Muller.1
Synonym(s):

  • partial loss-of-function mutation
  • weak mutation
  • hypomorph

Compare:

See also:

Reference(s):

1Muller, H. J. 1932. Further studies on the nature and causes of gene mutations. Proceedings of the 6th International Congress of Genetics, pp. 213–255.


You will also like...

Consciousness and behavior
Consciousness and Behavior

Human consciousness and behavior are an interesting topic since they are determined and controlled by the brain. Conscio..

Evolution of Life - Ancient Earth
Evolution of Life – Ancient Earth

Autotrophs flourished, absorbing carbon and light. Soon after, primitive life forms that could assimilate oxygen thrived..

Growth and Plant Hormones
Growth and Plant Hormones

Plants, like animals, produce hormones to regulate plant activities, including growth. They need these hormones to respo..

Gene Regulation in Eukaryotes
Gene Regulation in Eukaryotes

Learn about the general structure of a eukaryotic gene, the transcription factors, and post-transcriptional regulation....

kinesin motor proteins transporting molecules across microtubules
Movement of Molecules Across Cell Membranes

Molecules move within the cell or from one cell to another through different strategies. Transport may be in the form of..

Bryophytes
Bryophytes

Bryophytes (nonvascular plants) are a plant group characterized by lacking vascular tissues. They include the mosses, th..

Related Articles...

No related articles found

See all Related Topics