Dictionary > Hypomorphic mutation

Hypomorphic mutation

Definition
noun
(genetics) A type of mutation wherein the change in gene leads to the partial loss of the normal (wild-type) gene function, such as by reduced expression (of protein or RNA)
Supplement
Mutations involving recessive genes often results in the reduction or elimination of the gene function. When the function of the gene is completely eliminated the mutation is referred to as amorphic. But when the mutation leads to only a reduction in the gene function it is called hypomorphic. Thus, in the latter type of mutation, the function of the gene is not eliminated but reduced. Other types of mutations based on the effects on the phenotypes are antimorphic mutation, hypermorphic mutation, and neomorphic mutation. Both amorphic and hypomorphic mutations are associated with the loss of function due to a gene mutation. The other three, in contrast, are related to the “gain of function” of the gene. The terms were coined by the American geneticist, Hermann J. Muller.1
Synonym(s):

  • partial loss-of-function mutation
  • weak mutation
  • hypomorph

Compare:

See also:

Reference(s):

1Muller, H. J. 1932. Further studies on the nature and causes of gene mutations. Proceedings of the 6th International Congress of Genetics, pp. 213–255.


You will also like...

Golgi apparatus (3-D illustration)
Role of Golgi Apparatus & Endoplasmic Reticulum in Protein Synthesis

The endoplasmic reticulum and Golgi apparatus are the organelles involved in the translation step of protein synthesis a..

Crossing Over and Genetic Diversity
Inheritance and Probability

Gregor Mendel, an Austrian monk, is most famous in this field for his study of the phenotype of pea plants, including ..

Fossil trilobite imprint in the sediment
Insects

There are more species of insects than any other species combined. This surely illustrates that insects have the selecti..

A chart depicting Mendel's Law of Dominance
Mendel’s Law & Mendelian Genetics

One of Mendel’s law of inheritance is the “law of dominance”. Read this tutorial to know more about this form of i..

Regulation of Biological Systems
Regulation of Biological Systems

Regulation of Biological Systems tutorials are focused on the modulation of biological systems from cell to population l..

Pollution in Freshwater Ecosystems
Pollution in Freshwater Ecosystems

There are many environmental factors that arise due to the usage of water in one way or another and for every action tha..