Dictionary > Impalefection

Impalefection

Definition
noun
A method of delivering large molecules into cells using nanomaterials, such as carbon nanofibers, carbon nanotubes, and nanowires
Supplement
Transfection is the process by which the genetic material is delivered into the target cell. The process can be done through chemical and non-chemical methods. Impalefection is a non-chemical method, just as electroporation, cell squeezing, and sonoporation. However, the difference is that in impalefection the DNA is delivered into the cell using nanomaterials.
The nanomaterials used in impalefection includes carbon nanofibers, carbon nanotubes, and nanowires.1 These nanomaterials are coated with DNA. The latter is inserted into the recipient cell to deliver the genetic material. Other molecules that may be delivered by this method are certain proteins, antibodies, and so on.2 Cells that are impaired by the nanomaterial will express the delivered gene.
Word origin: derived from the combination of the words, impalement and infection
See also:

Reference(s):

1 McKnight, T. E., A. V. Melechko, D. K. Hensley, D. G. J. Mann, G. D. Griffin, and M. L. Simpson (2004). “Tracking gene expression after DNA delivery using spatially indexed nanofiber arrays”. Nano Letters 4 (7): 1213–1219. doi:10.1021/nl049504b

2Misra, A. (2010). Challenges in Delivery of Therapeutic Genomics and Proteomics. Elsevier B.V.


You will also like...

Ecological Research Measuring & Analysis
Ecological Research: Measuring & Analysis

This lesson is about the methods used for ecological research, such as quadrat and transect sampling, canopy fogging, an..

Growth Patterns
Growth Patterns

This tutorial describes the sigmoid curve, annual plant growth, tree growth, human growth, and insect growth as the grow..

Protein (illustration)
Protein Variety

The sequence of amino acids determines the type of protein. Protein is synthesized according to the sequence of nucleoti..

Buttress roots
Roots

This study guide tackles plant roots in greater detail. It delves into the development of plant roots, the root structur..

Oligodendrocyte and Schwann cell
The Central Nervous System

Myelin sheath is essential for a faster conductivity of signals. Know more about this feature of some neurons in the Cen..

Independent Assortment and Crossing Over
Independent Assortment and Crossing Over

This tutorial describes the independent assortment of chromosomes and crossing over as important events in meiosis. Read..

Related Articles...

No related articles found

See all Related Topics