Dictionary > Kinetochore

Kinetochore

Definition
noun, plural: kinetochores
A protein complex that assembles at the centromeric region of the chromosome during mitosis and meiosis
Supplement
The kinetochore is a protein structure. It forms at the centromere of every chromosome. Its main function is to bind microtubules of the spindle so that during metaphase the chromosomes would be able to properly align at the metaphase plate prior to anaphase, which is the pulling of chromosomes toward opposite poles of the cell. Thus, the kinetochore is important for the proper chromosome segregation.
In most animal cells, the kinetochore is a disc-like complex forming on the side of every chromatid where spindle fibers would attach to. Thus, a human mitotic chromosome, being comprised of two sister chromatids linked together via a centromere, would have two kinetochores situated in opposite directions at the centromeric region.
The kinetochore is comprised of an inner region (called inner kinetochore) and an outer region (called outer kinetochore). The inner kinetochore is tightly bound to the centromere DNA. The outer kinetochore is the one that interacts with the microtubules. Depending on the species, the number of microtubules attached to the kinetochore varies. In humans, there are about 15 microtubules attach to the kinetochore.
Unlike the outer kinetochore that forms and becomes functional only during mitosis and meiosis, the inner kinetochore persists throughout the cell cycle.
Word origin: Greek khôros (“space”)
See also:


You will also like...

Darwin's Finches - Natural Selection
Darwin and Natural Selection

This tutorial investigates the genetic diversity in more detail. It also delineates how certain alleles are favored over..

Birth of a Human Baby
Birth of a Human Baby

Following nine months inside the mother's womb is the birth of the baby. Know the different stages of the birthing proce..

Freshwater lake ecosystem
Freshwater Producers and Consumers

Freshwater ecosystem is comprised of four major constituents, namely elements and compounds, plants, consumers, and deco..

Disturbance on a still water
Abiotic Factors – Water Conditions

A still body of water may be disturbed by a variety of factors. One of them is wind. In fact, it is considered as the pr..

Homeostasis by water regulation
Homeostasis of Organism Water Regulation

Osmoregulation is the regulation of water concentrations in the bloodstream, effectively controlling the amount of water..

Ploidy
Polyploidy

Humans are diploid creatures. This means that for every chromosome in the body, there is another one to match it. Howeve..

Related Articles...

No related articles found

See all Related Topics