Dictionary > Myoblast

Myoblast

Definition
noun, plural: myoblasts
The embryonic progenitor cell of the muscle cell
Supplement
Myoblasts are the embryonic precursors of myocytes (also called muscle cells). Myoblasts differentiate into muscle cells through a process called myogenesis. During myogenesis, the myoblasts fuse into multi-nucleated myotubes, which later become the muscle fibers.1 During the early embryonic development, the myoblasts may either divide into other myoblasts or differentiate into myotubes. In vitro studies show that most myoblasts will divide mitotically when there is a sufficient concentration of growth factors. In contrast, an insufficient amount of growth factors lead to the cessation of cell division of myoblasts. This eventually results in the differentiation of myoblasts into myotubes. During the differentiation stage, certain genes (e.g. striated alpha-actin genes) are expressed and the myoblasts align with one another. The myoblasts, then, fuse with the recruitment of actin to the plasma membrane.2
Myoblasts may be classified as skeletal muscle myoblasts, smooth muscle myoblasts, and cardiac muscle myoblasts depending on the type of muscle cell that they will differentiate into.
Word origin: Ancient Greek mûs (mouse; muscle) + Ancient Greek blastós (germ, sprout)
See also:

  • myocyte
  • Myocyte enhancer factor 2C ‎

Reference(s):

1 Birbrair, Alexander; Zhang, Tan; Wang, Zhong-Min; Messi, Maria Laura; Enikolopov, Grigori N.; Mintz, Akiva; Delbono, Osvaldo (2013). “Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation”. Stem Cells and Development 22 (16): 2298–314.

2 Yaffe, David; Feldman, Michael (1965). “The formation of hybrid multinucleated muscle fibers from myoblasts of different genetic origin”. Developmental Biology 11 (2): 300.


You will also like...

Homeostatic Mechanisms and Cellular Communication
Homeostatic Mechanisms and Cellular Communication

Homeostasis is the relatively stable conditions of the internal environment that result from compensatory regulatory res..

Gene Pool and Speciation
The Gene Pool and Population Genetics

According to Charles Darwin's theory of natural selection, preferable genes are favored by nature in the gene pool, and ..

Cell Biology
Cell Biology

The cell is defined as the fundamental, functional unit of life. Some organisms are comprised of only one cell whereas o..

Crossing Over and Genetic Diversity
Inheritance and Probability

Gregor Mendel, an Austrian monk, is most famous in this field for his study of the phenotype of pea plants, including ..

Bryophytes
Bryophytes

Bryophytes (nonvascular plants) are a plant group characterized by lacking vascular tissues. They include the mosses, th..

Developmental Biology
Developmental Biology

Developmental biology is a biological science that is primarily concerned with how a living thing grows and attains matu..