Dictionary > Myogenesis

Myogenesis

Definition
noun
(embryology) The formation of muscle tissues through the differentiation of progenitor cells myoblasts into myocytes during the development of an embryo
Supplement
Myogenesis pertains to the developmental process in embryo where the myoblast differentiates into a muscle cell. The myoblasts are the progenitor cells of the muscle tissue. During embryonic development, the myoblasts either divide mitotically to give rise to more myoblasts or differentiate into myocytes or muscle cells. The decision as to either proliferate or differentiate is still unclear but in vitro studies showed that the presence of sufficient growth factors in a culture medium would result in the cell division of the myoblasts. In contrast, less growth factors in the medium resulted in the differentiation of the myoblasts. The stages of myogenesis are the following: delamination, migration, proliferation, determination, differentiation, specific Muscle Formation, and satellite cells. 1 In summary, the myoblasts begin to differentiate into myocytes by leaving the cell cycle and began expressing genes associated with the next stages. The myoblasts next align to one another and fuse. Genes that are essential during the fusion of myoblasts are myocyte enhancer factor-2 (Mef2) and twist transcription factor.
Word origin: Ancient Greek mûs (mouse; muscle) + Latin genesis (generation, nativity), from Ancient Greek génesis (origin, source, beginning, nativity, generation, production, creation)
See also:

Mentioned in:

  • Transcription factor HES 1 ‎
  • Integrin alpha-7

Reference(s):

1 Pestronk, Alan. “Myogenesis & Muscle Regeneration”. WU Neuromuscular. Washington University. Retrieved 2013-03-16.


You will also like...

Gene Regulation in Eukaryotes
Gene Regulation in Eukaryotes

Learn about the general structure of a eukaryotic gene, the transcription factors, and post-transcriptional regulation....

Mātauranga Māori and Science Collaboration
Mātauranga Māori and Science

Mātauranga Māori is the living knowledge system of the indigenous people of New Zealand, including the relationships t..

Body temperature regulation by the hypothalamus
Temperature Regulation in Animals

This tutorial elucidates body temperature regulation. Know the details here to learn how the body sets the body temperat..

Neurology of Illusions
Neurology of Illusions

Illusions are the perceptions and sensory data obtained from situations in which human error prevents us from seeing the..

green plant cells
Plant Cells vs. Animal Cells

Plant cells have plastids essential in photosynthesis. They also have an additional layer called cell wall on their cell..

Human gastrointestinal tract
Human Biology – Food and Digestion

This tutorial recognizes the importance of food as a source of energy that will fuel many biological processes. A good d..