Dictionary > Myogenesis

Myogenesis

Definition
noun
(embryology) The formation of muscle tissues through the differentiation of progenitor cells myoblasts into myocytes during the development of an embryo
Supplement
Myogenesis pertains to the developmental process in embryo where the myoblast differentiates into a muscle cell. The myoblasts are the progenitor cells of the muscle tissue. During embryonic development, the myoblasts either divide mitotically to give rise to more myoblasts or differentiate into myocytes or muscle cells. The decision as to either proliferate or differentiate is still unclear but in vitro studies showed that the presence of sufficient growth factors in a culture medium would result in the cell division of the myoblasts. In contrast, less growth factors in the medium resulted in the differentiation of the myoblasts. The stages of myogenesis are the following: delamination, migration, proliferation, determination, differentiation, specific Muscle Formation, and satellite cells. 1 In summary, the myoblasts begin to differentiate into myocytes by leaving the cell cycle and began expressing genes associated with the next stages. The myoblasts next align to one another and fuse. Genes that are essential during the fusion of myoblasts are myocyte enhancer factor-2 (Mef2) and twist transcription factor.
Word origin: Ancient Greek mûs (mouse; muscle) + Latin genesis (generation, nativity), from Ancient Greek génesis (origin, source, beginning, nativity, generation, production, creation)
See also:

Mentioned in:

  • Transcription factor HES 1 ‎
  • Integrin alpha-7

Reference(s):

1 Pestronk, Alan. “Myogenesis & Muscle Regeneration”. WU Neuromuscular. Washington University. Retrieved 2013-03-16.


You will also like...

Chromosome Mutations
Chromosome Mutations

Mutations can also influence the phenotype of an organism. This tutorial looks at the effects of chromosomal mutations, ..

Neurology of Illusions
Neurology of Illusions

Illusions are the perceptions and sensory data obtained from situations in which human error prevents us from seeing the..

Cell Respiration
Cell Respiration

Cell respiration is the process of creating ATP. It is "respiration" because it utilizes oxygen. Know the different stag..

DNA molecule
Genetic Control – On and Off Genes

Genes are the blueprint of our bodies, a blueprint that creates a variety of proteins essential to any organism's surviv..

mRNA
Protein Synthesis

Part of the genetic information is devoted to the synthesis of proteins. mRNA, a type of RNA, is produced as a transcri..

Genetics and Evolution
Genetics and Evolution

Humans are diploid creatures. This means that for every chromosome in the body, there is another one to match it. Howeve..

Related Articles...

No related articles found

See all Related Topics