Dictionary > Passive agglutination

Passive agglutination

Definition
noun
An agglutination reaction of inert particles coated with soluble antigen through an antiserum specific for the adsorbed antigen
Supplement
Agglutination basically pertains to the clumping of particles as it comes from the Latin word agglutinare, which means to glue. It occurs when an antigen is mixed with a corresponding antibody, isoagglutinin. This is the underlying principle in certain biological methods such as the identification of specific bacterial antigen and the identity of the bacteria as well.
Agglutination may be passive or active. In active agglutination, the complex formed from the reaction of antigen with the antibody is a large particulate whereas in passive agglutination, the resulting agglutination reaction would be observable only when the antigen is first attached to cetain particles, like latex beeds.
An example of the demonstration of passive agglutination is the agglutination reaction where a soluble antigen, for example gonadotropin is linked to inert particles, for example latex beads or tanned erythrocytes. Many antigens are able to couple with rbc and form stable reagents for antibody detection, e.g. antigens of E.coli, Yersinia, lipopolysaccharide of N. meningitides, toxoplasma, and so on.1
Compare:

Synonym(s):

  • indirect agglutination
  • See also:

    Related term(s):

  • agglutination
  • reverse passive agglutination
  • Reference(s):

    1 Rao, C. Vaman. An introduction to immunology. Boca Raton: CRC Press; 2002.


    You will also like...

    Freshwater aquatic plankton
    Freshwater Communities & Plankton

    Planktons are microscopic organisms that live suspended in aquatic habitats. There are two groups: the phytoplanktons an..

    An artist's depiction of the origin of amphibians
    Amphibians & Early Reptiles

    Obtaining air outside an aquatic environment required species to acquire suitable adaptations, and this was the case of ..

    Physiological Homeostasis
    Physiological Homeostasis

    Homeostasis is essential to maintain conditions within the tolerable limits. Otherwise, the body will fail to function p..

    Salmon jumping upstream in the river
    Lotic Communities & Animals

    A running water environment offers numerous microhabitats for many types of animals. Similar to plants, animals in lotic..

    The Human Physiology
    The Human Physiology

    Physiology is the study of how living organisms function. Thus, human physiology deals specifically with the physiologic..

    Still freshwater and plants
    Still Freshwater & Plants

    Plants in lentic habitats have features not found in terrestrial plants. They acquired these features as they adapt to t..

    Related Articles...

    No related articles found

    See all Related Topics