Dictionary > Prion

Prion

prion
Origin: proteinaceous infectious particle
(microbiology) an infectious protein particle similar to a virus but lacking nucleic acid; thought to be the agent responsible for scrapie and other degenerative diseases of the nervous system.
The word, for proteinaceous infectious agent, was coined in 1982 by neurologist stanley Prusiner as part of a hypothesis regarding ailments bearing aetiologic resemblance to those caused by slow viruses (for instance, kuru). The hypothesis has been borne out by investigation. Prions are now believed responsible for several transmissible neurodegenerative diseases such as creutzfeldt-jakob disease (CJD), the human form of mad cow disease.
prions are infectious proteinaceous particles that lack nucleic acid. Prions are said to be in the border zone between nonliving and living things because they have no need to metabolize or the capacity to reproduce but they are capable of replication within the body of a human or of some mammals.
prions can gain entry into the body mainly by ingestion, e.g. of contaminated human Growth Hormone or of contaminated blood or blood products. Prions may also arise from a mutation in the gene that encodes the protein. They not only fold into unusual shapes but also seem to have the ability to cause other (normal) proteins to alter their shape as well.
Since in general the disease would show symptoms only after more than 30 years the prions have already accumulated and attacked nerve cells or brain tissues, leaving spongelike holes. Prion diseases have both infectious and hereditary components. The gene that codes for prions can mutate and be passed on to the next generation. Most of the diseases also can be acquired directly by infection, but unlike other infectious agents, prions provoke no immune response.


You will also like...

Growth Patterns
Growth Patterns

This tutorial describes the sigmoid curve, annual plant growth, tree growth, human growth, and insect growth as the grow..

Oligodendrocyte and Schwann cell
The Central Nervous System

Myelin sheath is essential for a faster conductivity of signals. Know more about this feature of some neurons in the Cen..

Homeostatic Mechanisms and Cellular Communication
Homeostatic Mechanisms and Cellular Communication

Homeostasis is the relatively stable conditions of the internal environment that result from compensatory regulatory res..

Population Regulation in an Ecosystem
Population Regulation in an Ecosystem

With regard to the population size of a species and what factors may affect them, two factors have been defined. They ar..

An artist's depiction of the origin of amphibians
Amphibians & Early Reptiles

Obtaining air outside an aquatic environment required species to acquire suitable adaptations, and this was the case of ..

Nephrolepis exaltata
Vascular Plants: Ferns and Relatives

Ferns and their relatives are vascular plants, meaning they have xylem and phloem tissues. Because of the presence of va..

Related Articles...

No related articles found

See all Related Topics