Dictionary > Tropomyosin


A long protein strand composed of two fully alpha helical chains in a coiled-coil dimmer, and binds along the length of the actin filament. It is also bound to bead-like protein complex (troponin) in which, together, they regulate the actin-myosin interations in muscle contraction.
The tropomyosin, together with troponin, acts like a “molecular switch” that controls the interaction of actin and myosin.
In the absence of a nerve impulse, the tropomyosin lies fittingly on the groove of the actin filament, blocking the myosin-binding sites in actin. At this point the muscle is said to be relaxed or at rest. In the presence of nerve impulse, a cascade of reactions occurs that causes the release of calcium ions (from the sarcoplasmic reticulum). The calcium then binds to troponin, which causes a shift in the position of tropomyosin-troponin on the actin filament, unblocking the myosin-binding sites. This allows the myosin heads to bind with actin molecules, resulting in muscle shortening and contraction. Soon, the calcium levels become low again that the troponin-tropomyosin shifts back, blocking the myosin-binding sites again.
See also: troponin, actin filament

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