Dictionary > Acrocentric chromosome

Acrocentric chromosome

Definition
noun, plural: acrocentric chromosomes
A chromosome whose centromere is subterminal resulting in its q arms being longer than its p arms
Supplement
The centromere is the dense, constricted region in a chromosome. It contains highly-specialized repetitive DNA sequences (e.g. satellite DNA) that are packaged into heterochromatin. The centromere serves as the site for kinetochore assembly and therefore it is essential during the alignment of the chromosomes at the metaphase plate and the subsequent segregation of chromosomes during cellular division. The presence of the centromere results in the characterization of the chromosomal arms. The arm that is relatively shorter is called p whereas the one that is longer is called q. Based on the position of the centromere, the chromosome may be described as metacentric, submetacentric, acrocentric, telocentric, subtelocentric, and holocentric.
An acrocentric chromosome is a chromosome whose centromere is subterminal. The centromere is closer to the end rather than the center. It should not be confused with subtelocentric chromosome wherein the centromere is comparatively nearer to the end than that of the centromere of an acrocentric chromosome.
In humans, chromosome 13, chromosome 14, chromosome 15, chromosome 21, chromosome 22, and Y chromosome are acrocentric.
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