Dictionary > Induced fit model

Induced fit model

induced fit model definition and example

Induced fit model
n., [ɪnˈduːst fɪt ˈmɑdl̩]
Definition: an enzyme-substrate interaction depicting that both the enzyme and substrate undergo changes to attain an optimal fit

Induced-Fit Model Definition

The induced-fit model is a model for enzymesubstrate interaction to describe that the substrate is capable of inducing the proper alignment of the active site of the enzyme, causing the latter to subsequently perform its catalytic function.

It is opposed to the lock-and-key model that is also used to describe the enzyme-substrate interaction. In the induced fit model, both the substrate and the active site of the enzyme change in conformation until the substrate is completely bound to the enzyme, at which point the final shape and charge is determined. This activates the enzyme into performing its catalytic function.

The induced-fit model was suggested by Daniel Koshland in 1958. It is the more accepted model for enzyme-substrate complex than the lock-and-key model. In the lock-and-key model, the interaction of the substrate and the enzyme is likened to a key (the substrate) that is highly specific to the lock (the active site of the enzyme). It depicts a rather static and rigid form of interaction. Unlike the lock-and-key model, the induced fit model shows that enzymes are rather flexible structures in which the active site continually reshapes by its interactions with the substrate until the time the substrate is completely bound to it.

See the figures below to compare the two. Or, watch the vid below for the differences between the two models.

induced fit model definition and example

Lock and key model definition and example



Try to answer the quiz below to check what you have learned so far about Induced-fit Model.


Choose the best answer. 

1. A flexible enzyme-substrate interaction
2. Involves conformational changes
3. Highly specific
4. Suggested by Daniel Koshland in 1958
5. Which of the following depicts an induced fit model?

Send Your Results (Optional)

Your Name
To Email


See also:

©BiologyOnline.com. Content provided and moderated by Biology Online Editors.

You will also like...

Neurology of Illusions
Neurology of Illusions

Illusions are the perceptions and sensory data obtained from situations in which human error prevents us from seeing the..

Biological Cell schematic diagram
Biological Cell Introduction

It only takes one biological cell to create an organism. A single cell is able to keep itself functional through its 'mi..

Biological Energy
ATP & ADP – Biological Energy

ATP is the energy source that is typically used by an organism in its daily activities. The name is based on its structu..

Adaptive Radiation
Adaptive Radiation

The diversification of several new species from a recent ancestral source, each adapted to utilize or occupy a vacant ad..

Water in Plants

The movement of molecules (specifically, water and solutes) is vital to the understanding of plant processes. This tuto..

New Zealand Fauna
New Zealand’s Unique Fauna

Meet some of New Zealand's unique fauna, including endemic insects, frogs, reptiles, birds, and mammals, and investigate..

Related Articles...

No related articles found

See all Related Topics