Dictionary > Nonsense mutation

Nonsense mutation

Definition
noun, plural: nonsense mutations
A form of point mutation resulting in a nonsense codon that does not code for an amino acid and leads to a protein product that is early truncated
Supplement
Mutation is a change in the nucleotide sequence of a gene or a chromosome. When there is only one nucleotide involved, it is particularly referred to as a point mutation. Point mutation occurring in noncoding sequences often does not result in an altered amino acid sequence during translation. However, if a mutation in the promoter sequence of a gene occurs, the effect may be apparent since the expression of the gene may cause changes in the amino acid sequence, as well as the structure and function of the protein product. Point mutations may be classified based on functionality: (1) nonsense mutation, (2) missense mutation, and (3) silent mutation.
A nonsense mutation is a type of mutation resulting in a nonsense codon. The nonsense codon, as the name implies, would not code for an amino acid. A possible outcome is a protein product that is early truncated, incomplete and often nonfunctional. Genetic disease such as Duchenne muscular dystrophy is caused by a nonsense mutation in gene responsible for a specific protein, for example, dystrophin.
Compare:

See also:

  • point mutation
  • mutation
  • substitution mutation


    You will also like...

    Balanced Diet
    A Balanced Diet – Minerals and Proteins

    Proteins and minerals can be derived from various dietary sources. They are essential for the proper growth and developm..

    Freshwater aquatic plankton
    Freshwater Communities & Plankton

    Planktons are microscopic organisms that live suspended in aquatic habitats. There are two groups: the phytoplanktons an..

    Physiological Homeostasis
    Physiological Homeostasis

    Homeostasis is essential to maintain conditions within the tolerable limits. Otherwise, the body will fail to function p..

    Human gastrointestinal tract
    Human Biology – Food and Digestion

    This tutorial recognizes the importance of food as a source of energy that will fuel many biological processes. A good d..

    Growth and Plant Hormones
    Growth and Plant Hormones

    Plants, like animals, produce hormones to regulate plant activities, including growth. They need these hormones to respo..

    Thermographic image of face and neck
    Regulation of Organic Metabolism, Growth and Energy Balance

    The human body is capable of regulating growth and energy balance through various feedback mechanisms. Get to know the e..