Dictionary > Substitution mutation

Substitution mutation

noun, plural: substitution mutations
(genetics) A small-scale mutation characterized by a substitution of one or few nucleotides of a gene
Mutation is a change in the nucleotide sequence of a gene or a chromosome. Based on the effect of mutation on the gene structure, mutations may be: (1) small-scale mutations or (2) large scale mutations. Small-scale mutations are a type of mutation where one or few nucleotides of a gene are affected. They are further classified as follows: (1) substitution mutations, (2) insertion mutations, and (3) deletion mutations.
Substitution mutations are a type of mutation in which a single nucleotide is substituted with a different nucleotide. Examples of (base-pair) substitutions: a purine is substituted with a different purine (A ā†’ G) or a pyrimidine, for a different pyrimidine (C ā†’ T). This type of substitution mutation is referred to as transition. Another type of base-pair substitution is the so-called transversion. In transversion, a purine is substituted with a pyrimidine or a pyrimidine with a purine.
Substitution mutations may also be typified into: silent mutations, missense mutations, and nonsense mutations.
Substitution mutation is sometimes referred to as point mutation. However, point mutation is defined particularly as a type of mutation involving a change of only one nucleotide.
See also:

You will also like...

Community Patterns

Learn about community patterns and the ecological factors influencing these patterns. Revisit some of the ecosystems you..

Buttress roots

This study guide tackles plant roots in greater detail. It delves into the development of plant roots, the root structur..

Still Water Community Plants
Still Water Community Plants

This tutorial looks at the adaptations of freshwater plants for them to thrive in still water habitats. Familiarize your..

New Zealand Flora & Fauna
Ecology & Biodiversity: New Zealand Flora & Fauna

New Zealand is known for its unique biodiversity, caused by its remarkable geography and geologic history. Breaking away..

The Hominids

The hominid family diversified from the apes around 6 to 8 million years ago. Since then, the evolutionary path has prov..

Lake Wakatipu, New Zealand
New Zealandā€™s Unique Geographical History

Explore why New Zealand has such unique flora and fauna, and learn why long periods of geographical isolation. This less..