Dictionary > Signal peptide

Signal peptide

Definition
noun
An extra-peptide extension found at the amino terminus of a nascent protein, and functions by prompting the transport mechanism within the cell to bring it to its specific destination within the cell, i.e. the endoplasmic reticulum into the secretory pathway
Supplement
Signal peptide, commonly comprised of a chain of approximately 20 amino acids, is essential because it directs the protein where it should go. If the protein is for secretion (transport outside the cell), then, the signal peptide is necessary to direct the protein to the endoplasmic reticulum where it will grow further and mature to ready for secretion. The signal peptide is recognized by the signal recognition particle (SRP) and cleaved by the signal peptidase following transport at the endoplasmic reticulum.
Synonym(s):

See also:

  • signal recognition particle
  • signal peptidase
  • Reference(s):

    • 1 Duffaud GD, Lehnhardt SK, March PE, Inouye M. 1985. Structure and Function of the Signal Peptide. In: Knauf PA, Cook JS. Membrane protein biosynthesis and turnover. Florida: Academic Press. P.65-104.


    You will also like...

    Genetics and Evolution
    Genetics and Evolution

    Humans are diploid creatures. This means that for every chromosome in the body, there is another one to match it. Howeve..

    Cambial cells
    Plant Tissues

    Plant organs are comprised of tissues working together for a common function. The different types of plant tissues are m..

    Homeostatic Mechanisms and Cellular Communication
    Homeostatic Mechanisms and Cellular Communication

    Homeostasis is the relatively stable conditions of the internal environment that result from compensatory regulatory res..

    Cells in different stages of meiosis
    Meiosis – The Genetics of Reproduction

    Meiosis is a form of cell division that creates gametes. It is comprised of two divisions that in the end, the resulting..

    Salmon jumping upstream in the river
    Lotic Communities & Animals

    A running water environment offers numerous microhabitats for many types of animals. Similar to plants, animals in lotic..

    DNA - schematic
    Genetic Mutations

    This tutorial looks at the mutation at the gene level and the harm it may bring. Learn about single nucleotide polymorph..