Dictionary > Gene gun

Gene gun

Definition
noun
A method of transferring large molecules such as DNA into the cell by coupling the DNA to a nanoparticle of an inert solid (typically gold) to be injected into the nucleus of the target cell
Supplement
Molecules such as DNA, RNA, proteins, and others can be moved into the target cell. The process is called transfection. It is carried out in order for those molecules to be delivered into the semi-impermeable plasma membrane of the cell. The possible applications of transfection are for therapeutic purposes (i.e. gene therapy) or for research.
Several methods are used nowadays for transfection. One of them is the gene gun. It is regarded as a biolistic particle delivery system because the nanoparticle of an inert solid (e.g. gold) carrying the target gene on its surface is fired into the target cell at very high speeds.
Gene guns are originally used for transfecting plant cells. However, Gene guns can also be used in human and animal cells. For instance, gene gun can be used to deliver DNA vaccine. It is also used in labeling subsets of cells in cultured tissue.
”Synonym(s):

  • bioballistics
  • biolistics

See also:

  • transfection
  • gene
  • genetic material
  • electroporation
  • cell squeezing
  • sonoporation
  • optical transfection
  • protoplast fusion
  • impalefection
  • hydrodynamic delivery


  • You will also like...

    Human Neurology
    Human Neurology

    Human Neurology deals essentially with the nervous system of humans. It also features the various theories put forward b..

    DNA - schematic
    Genetic Mutations

    This tutorial looks at the mutation at the gene level and the harm it may bring. Learn about single nucleotide polymorph..

    3D rendering of an antibody
    Passive and Active Types of Immunity

    Lymphocytes are a type of white blood cell capable of producing a specific immune response to unique antigens. In thi..

    New Zealand - Biodiversity fauna
    New Zealand’s Biodiversity

    Find out more about New Zealand's unique biodiversity by exploring a range of different ecosystems and the key role of s..

    Developmental Biology
    Developmental Biology

    Developmental biology is a biological science that is primarily concerned with how a living thing grows and attains matu..

    Lentic community
    Freshwater Communities & Lentic Waters

    Lentic or still water communities can vary greatly in appearance -- from a small temporary puddle to a large lake. The s..

    Related Articles...

    No related articles found

    See all Related Topics