Dictionary > Gene gun

Gene gun

Definition
noun
A method of transferring large molecules such as DNA into the cell by coupling the DNA to a nanoparticle of an inert solid (typically gold) to be injected into the nucleus of the target cell
Supplement
Molecules such as DNA, RNA, proteins, and others can be moved into the target cell. The process is called transfection. It is carried out in order for those molecules to be delivered into the semi-impermeable plasma membrane of the cell. The possible applications of transfection are for therapeutic purposes (i.e. gene therapy) or for research.
Several methods are used nowadays for transfection. One of them is the gene gun. It is regarded as a biolistic particle delivery system because the nanoparticle of an inert solid (e.g. gold) carrying the target gene on its surface is fired into the target cell at very high speeds.
Gene guns are originally used for transfecting plant cells. However, Gene guns can also be used in human and animal cells. For instance, gene gun can be used to deliver DNA vaccine. It is also used in labeling subsets of cells in cultured tissue.
”Synonym(s):

  • bioballistics
  • biolistics

See also:

  • transfection
  • gene
  • genetic material
  • electroporation
  • cell squeezing
  • sonoporation
  • optical transfection
  • protoplast fusion
  • impalefection
  • hydrodynamic delivery


  • You will also like...

    Cell Respiration
    Cell Respiration

    Cell respiration is the process of creating ATP. It is "respiration" because it utilizes oxygen. Know the different stag..

    Cells in different stages of meiosis
    Meiosis – The Genetics of Reproduction

    Meiosis is a form of cell division that creates gametes. It is comprised of two divisions that in the end, the resulting..

    Gene Regulation in Eukaryotes
    Gene Regulation in Eukaryotes

    Learn about the general structure of a eukaryotic gene, the transcription factors, and post-transcriptional regulation....

    genes controlling growth and development
    Control of Growth & Development

    Control of Growth & Development tutorials look at how the genetic makeup determines the biological processes on a da..

    Structural depiction of catalase, an enzyme
    Protein Activity and Cellular Metabolism

    Proteins have a crucial role in various biological activities. Get to know how proteins are able to perform as enzymes, ..

    Balanced Diet
    A Balanced Diet – Minerals and Proteins

    Proteins and minerals can be derived from various dietary sources. They are essential for the proper growth and developm..

    Related Articles...

    No related articles found

    See all Related Topics